Many governments face a trade-off between health and economy during the coronavirus pandemic. Social distancing and lockdown caused decline in gross domestic product of coronavirus affected countries. In this study, by using the input-output table of 2011, the hypothetical extraction method is used to extract 10 selected economic activities hypothetically from economic system and examine the direct and indirect effect of this extraction on Iran’s gross output. Results show that extraction of passenger transport, aviculture and clothing sectors result in the greatest reductions in gross domestic product. Furthermore, extraction of accommodation services, travel agency and tour operator activities and foodservice industry as representative of the tourism sector is able to reduce total output by almost one percent. Considering these ten selected sectors, 6.5 percent of Iran’s total economic output would be impacted by coronavirus outbreak.