The purpose of the present study was to evaluate reliability and validity of Persian version of the Exercise Dependence Scale-Revised in Gorganian Bodybuilder men. After a rigorous translation and back-translation procedure, 400 men completed the Drive for Muscularity Scale (DMS), the Exercise Dependence Scale-Revised (EDS-R), the Eating Disorders Examination-Questionnaire (EDE-Q), and the Clinical Impairment Assessment (CIA). The reliability of the scale was assessed via internal consistency. Cronbach’s alphas range (0.76 to 0.82) suggested good reliability of the Persian version of EDS-R. Confirmatory factor analysis supported the original seven factor model of the scale. The internal relations between the subscales (0.22 to 0.59) and concurrent validity (0.09 to 0.78) also were appropriate. The Persian version of the Exercise Dependence Scale-Revised has a satisfactory psychometric properties in the Iranian society and useable in the clinical and research settings.