This study examined the comparison of exercise self-efficacy and indices of well-being based on different orientations to activities among physically-motion disables and veterans. 123 physically-motion disables and veterans filled the questionnaires of exercise self-efficacy, hedonia and eudemonia motives for activities, positive and negative affect and subjective vitality.The results showed that only eudemonia motive positively associated with positive affect and vitality. Exercise self-efficacy positively associated with eudemonic well-being. There were significant differences between different orientation to activities on positive affect and vitality. People whose lives were high in eudemonia had higher degrees of positive affect and vitality than people whose lives in the lower degree of both hedonia and eudemonia (empty life). Also, people whose lives were in both high eudemonia and hedonia (full life) had the higher degree of positive affect than people whose lives in empty life.The finding show of crucial role of eudemonia on well-being among physically-motion disables and veterans, and the combination of hedonia and eudemonia may be associated with optimal well-being.