The main objective of this study is to explain the role of social (intra and extra-university) and individual factors of academic burnout among university students, measured by the three components of “academic exhaustion”, “academic disinterest” and “academic inefficacy”. The present study is a survey of 329 undergraduate and graduate students of the University of Isfahan, selected through stratified sampling method across a variety of disciplines. The results showed that academic motivelessness, educational satisfaction, hope for future employment and academic participation have a direct impact on academic burnout while the interaction between faculties and students, departmental atmosphere, symbolic capital, and significant others have an indirect impact. Also, the quality of the learning environment and contact with classmates did not show a significant relationship. The results showed that the most important causes of academic burnout among students are lack of motivation, dissatisfaction with education, disappointment in future employment and lack of academic participation. As a whole, the results suggest that social factors through individual factors and their complex combination have an undeniable impact on academic burnout.