AIDS as a chronic dangerous disease is one of the major causes of mortality in the world. The aim of this study was to compare of looming maladaptive style, negative problem-orientation, interpersonal emotion regulation, emotional processing style, and rejection sensitivity in the patients with AIDS and healthy people. the method of this study was descriptive from its comparative casual types. The population was all of patients with AIDS were referred to health center in the urmia. The Sample was 40 patients with AIDS were referred to health center in the urmia and 40 healthy people were selected by available sampling method. Data were analyzed by Multivariate Analysis of Variance and one-way analysis of variance. the results showed that there is significant deference between two groups in the variables of looming maladaptive style, negative problem-orientation, interpersonal emotion regulation, emotional processing styles and rejection sensitivity and patients with AIDS get the higher scores in these variables. it can be concluded that many psychological problems that these patients experience are in part as a result of cognitive, emotional and social factors that have been studied in this study. Then, paying attention to these factors in the etiology and treatment of psychological problems of these patients can be a useful step in the reducing of these problems and improving of mental health in the patients.