The aim of the study, study of Changes in adiponectin, leptin, and plasma lipid profile of Inactive men the  result 24 session, playing futsal. In this study, 20 healthy men 20 to 30 years old, the experimental group (age: 23/5±2/58, weight: 69/36±14/48, body composition: 22/82±4/41) of controls (age: 24/6±2, weight: 68/22±12/71, body composition: 21/99±3/58) inactive randomly divided into control and experimental groups. Experimental groups in each session, indoor futsal training program for eight weeks and will run three sessions per week, while the control group had normal activity. Before the training program, and 48 h after the last session of play, 5 ml blood samples for measurement of adiponectin, leptin, and plasma lipid profile, blood was collected from the participants. After 48 hours of the last training session before the test was re-sampled in the same conditions. T-test results showed that exercise increased adiponectin and high-density lipoprotein and decreased leptin, low density lipoprotein, lipoprotein (a), triglycerides and cholesterol are, however, differences in adiponectin was not significant (P≤0.05). Overall, this study can be taken that these exercises in a short period of eight weeks futsal, adiponectin does not cause significant changes but the significant changes in leptin, high-density lipoprotein, low density lipoprotein, lipoprotein (a), triglycerides and cholesterol in the blood plasma.