The most common side effect of physical activity is the risk of musculoskeletal damage, that anterior cruciate ligament injury is the most common one. Purpose of the study is comparing the effect of six weeks of comprehensive injury prevention training on anterior cruciate ligament with internal and external feedback on the proprioception and knee function of active female university students. Forty five active female university students aged 18-25 years were volunteered and randomly assigned to three groups (internal, external and control) and they performed the protocol three times a week for six weeks. Proprioception and function of the knee joint were measured using goniometer and functional tests in two stages  namely pre-test and post-test. Statistical analysis of covariance, paired t test and Tukeychr('39')s post hoc tests were used for statistical analysis with a significant level of p≤0.05. Overall results of the study showed that the present exercise protocol with internal and external feedback had a significant effect on the proprioception of p≤0.001 and p=0.000 for the knee performance and there was no significant difference between the two training groups. Regarding the results of the study, it is suggested that the present training protocol be addressed by coaches and sport sciences specialists as a complementary tool and method, along with other training methods, for those who are prone to damage to the anterior cruciate ligament.