Time under Tension of muscle is one of the variables of strength training that contributes to its adaptation. The present study was conducted the effects of six weeks of resistance training with the varying Time under Tension of muscle on VEGF and endosotene serum levels  in healthy young women. This study was conducted on 20 female students (22.65±2.03years) Subjects were randomly and equally assigned to two groups with a Time under Tension of 1s- 1s(Normal Speed Contraction) and 3s- 3s (slow Speed Contraction). The exercise load was the same in both groups and resistance training was done in a circular manner for six weeks, three days a week in eight stations. Blood samples were taken from the subjects to study  research variables before the training period and 48h after the last session of the training. Data were analyzed by covariance analysis at a significant level of P≤0.05. There was no significant difference between the serum levels of VEGF and endostein in both groups (P≥0.05). In the strength test, the  SSC group experienced increase power further. However, there was no difference between the two groups in indicators related to angiogenesis for six weeks and  most probably, for this indicator needed more training time, but  practice with more Time under Tension (3s- 3s) can lead to increase power further.